I didn’t realize until recently how important Apigenin turns out to be in my fight against PCa. As my research broadened, Genistein also came into the picture as a significant fighter of PCa. The anticancer efficacies of these two flavones can be confirmed by in-vitro and in-vivo studies. (1)
Here is another key research paper that shows that “Apigenin has been shown to have antioxidant, anti-inflammatory, and anti-cancer properties. In vitro studies have demonstrated that apigenin inhibits the growth of cancer cells, induces cell cycle arrest, and promotes apoptosis. Additionally, apigenin has been shown to modulate signaling pathways involved in cell proliferation and survival and to inhibit angiogenesis and metastasis.” (2)
There are many, many more papers, going back up to 20 years ago. The first paper I show here was published in 2025 and the second one was 2023. While I have read through several more, I don’t think I need more information about it to feel as though getting as much Apigenin into my system as possible is a good idea.
Thankfully, Apigenin’s most abundant source comes from Parsley, which is not very expensive. And the Dried Parsley contains amazing amounts of Apigenin.
| Food | Apigenin Content (approximate) |
|---|---|
| Dried Parsley | up to 45 mg per gram |
| Fresh Parsley | 2.15 mg per gram |
| Chamomile Flowers (dried) | 3–5 mg per gram |
| Celery (fresh leaves) | 0.5625 mg per gram |
| Celery Seed | 786.5 μg per gram |
| Vine Spinach | 622 μg per gram |
| Chinese Celery | 240.2 μg per gram |
| Celery Stalks | 5.15 mg per 100 grams |
Nothing else comes close in Apigenin content, so for me it’s a no-brainer. I have added two heaping teaspoons to my Year 2 Morning Routine at the Counter. Two heaping teaspoons masses to 3g, so I am getting 135mg of Apigenin a day. At $2.23/oz, that’s 6.7 cents per gram, so 20 cents a day, or $6 a month. It costs only a few dollars at BJs for a container that lasts a few weeks. Ordering online also works for when I don’t want to drive !
I remain most hopeful with respect to Apigenin, which comes in various pill forms, two of which are 50 mg and 500 mg. I like the 500 mg because high I can tolerate high doses and in this case the higher dose is less expensive than the lower dose per mg. The 500 mg is a Liposomal gel cap which enhances absorbability.
In an effort to significantly increase Apigenin intake, I scoured Google Scholar, running across this research paper, which sources its Apigenin for its testing calling out this reference number: CAS# 520–36–5. The paper says that research-grade Apigenin requires preparation before ingestion, and then apparently calls out a reasonably simple protocol of placing it in capsules, without any other fanfare.
“Purified forms of apigenin itself (CAS# 520–36–5) are however readily available for research purposes and could be upscaled for human ingestion following appropriate protocols. Purity levels of 95–98% are available from multiple suppliers globally, both sourced from natural products (citrus, chamomile) and synthetic. Naturally sourced apigenin is purified via chromatographic methods and produced in powder or recrystallized forms. Incorporation into capsules at a typical 97% purity level would not compromise feasibility and other than the capsule casing comprised of cellulose or gelatin, no other excipients (binding agents, lubricants, fillers, colors) would be required.” (3)
I find it exciting adding another, what I consider, major PCa fighting strategy to complement everything else I am doing. And my Spidey-senses detect synergistic effects with these strategies in combination. For example, one Apigenin study calls out the importance of Rosmarinic Acid, abundant in Ground Rosemary, a part of my Ursolic Acid Strategy. And the Zinc Strategy requires a short list of helpers, 80% of which I am already taking. So I just added a daily Zinc supplement.
Good Science to Everyone !
Leave a Reply