November 26, 2025
Another blogger suggests Luteolin is the better researched and more promising anti PCa micronutrient as compared to Apigenin. And I am already taking large amounts of Punicic Acid through pomegranate seed oil. How do I properly step up either Luteolin or Apigenin to demonstrated levels of PCa cellular kills ? And how do I know whether my high dose of Punicic Acid rises to the proper level?
For these three potential remedies, I need to know what uMol/L concentration to target, where can I get high concentrations from reliable sources, and how to ready them for consumption.
Concentration Targets
Apigenin
I have a micromolar blood concentration recommended for Apigenin of between 5 and 20 umol/L.
Punicic Acid
The Punicic Acid table I will show again here.
This graph and table shows 10 uMol/L as sufficient to kill 5 of 6 PCa research cell lines at a 50% rate (IC50). Even the 22RV1 experiences a 30% death rate. 22RV1 is a PCa line that is androgen-independent.
Luteolin
I do not have a recommended blood concentration for Luteolin yet.
High Purity Sources
Ingestion by mouth requires a high purity source to reach recommended therapeutic blood concentration levels. The following high purity sources are research grade, used by researchers for their testing and reporting out in their University research papers. So that makes them good because they are reasonably certain to contain what they say. It’s bad because it’s not ready for ingestion by mouth, as stated in one paper this way:
“Purified forms of apigenin itself (CAS# 520–36–5) are however readily available for research purposes and could be upscaled for human ingestion following appropriate protocols. Purity levels of 95–98% are available from multiple suppliers globally, both sourced from natural products (citrus, chamomile) and synthetic. Naturally sourced apigenin is purified via chromatographic methods and produced in powder or recrystallized forms. Incorporation into capsules at a typical 97% purity level would not compromise feasibility and other than the capsule casing comprised of cellulose or gelatin, no other excipients (binding agents, lubricants, fillers, colors) would be required.” (3)
The CSA number refers to the Chemical Abstract Service number, assigned to identify chemical products. I have recently discovered a source for research grade Apigenin at 97% and Luteolin at 90%. I need to run them by whatever expert opinions I can get as well as learn how to ready them for consumption. Although in the case of the Apigenin, preparation may only require filling capsules. Here is a batch from May of 2025.
November 24, 2025
After a good night’s sleep and further combing through this Apigenin research paper, I have extracted the following information that I can use to calculate a reasonable dosage for me to yield a 5μmol/L plasma concentration of Apigenin recommended by the paper to fight cancer. It should be noted that this paper does not specifically focus on PCa, but rather on Apigenin. However, I am confident with all the other supporting research papers out there on how Apigenin fights PCa, this information will create an actionable formulation for me.
What I have been doing, taking 2 tablespoons of Parsley, falls well short of the dosage required to reach the 5μmol/L target. However,according to this subsection of the paper, a 70kg man can take 2 large 1.4 ml capsules of 97% purity Apigenin to achieve the 5μmol/L target. Very exciting to have this sort of information explicitly worked out in the research paper itself. I do wish to review this section of the paper over and over again to gain a complete understanding of the calculations, and I do want to look forward into papers that cite this paper in their research and see how this paper shaped said derivative research.
November 23, 2025
Revisiting the Apigenin paper from yesterday, it calls for a circulating blood concentration for efficacy of 1–5μmol/L as the target. The paper rules out dried Parsley or other direct methods as too difficult do to “heroic portions” (2.5 cups of dried parsley a dose), but says supplements will work. After a second read and a dive into its references I hope to find out exactly how much I need to take.
November 22, 2025
After warming up our Adirondack Country Cottage and taking a well-deserved nap following a 5 hour drive, I am up early this morning, thinking more about Apigenin and its apparently amazing fighting ability against PCa. This draws me into another dive into Google Scholar with the issue of absorbability top of mind. So I enter “apigenin and piperine fight PCa” which returns a huge list of research papers, but piperine isn’t showing up. Recall that piperine is the active ingredient in black pepper that research has shown improves absorbability of ursolic acid by 10 times. I have been wondering if piperine could also work its magic on Apigenin.
This has led me to conduct another few hours of research, scanning countless dead-end papers. And then I ran across a very interesting research paper published in 2021 that discusses whether it’s possible to obtain the anti-cancer benefits of Apigenin by eating foods or plants high in Apigenin and/or by other methods such as taking Apigenin supplements. It’s an interesting article since it includes information from out-of-body cellular research, animal research, and human research. And there is no troublesome paywall that I have to find a way to breach if I want to read it in it’s entirety, which is in and of itself, no small feat.
First, I like the fact that this paper, along with other papers, see that Apigenin is a proven anti-cancer biologic molecule. Many other papers also focus specially on its specific anti PCa attributes.
So after a quick first scan through the document for an hour or so, it seems to come to the conclusion that there is a measurable concentration of Apigenin in the blood that reaches therapeutic levels that inhibits cancer growth and kills cancer. However, attempts to reach that therapeutic concentration in the blood appears difficult by merely taking Parsley and eating it, because that may require someone to eat 2.5 cups of parsley a day ! ( a so-called heroic amount ) It is interesting to think that if one could eat such a amount that this paper believes it would result in concentrations of Apigenin that would effectively attack cancer, slowing its growth and ability to metastasize, and also kill it.
This paper does go on to say that research supplements do reach the levels of concentrations necessary to be able to take them by mouth and achieve the proper levels, but that some type of preconditioning would be necessary to convert lab research grade Apigenin concentrate into something a human could consume.
This is all very encouraging. I need more rest to recharge for the next dive into this paper with the intention of developing a new and improved action for me to take to max the ability of Apigenin to fight and kill my PCa. My mind turns to the idea of reading other papers that may have been published after 2021 that reference this paper, papers that may shed more light on how to create an effective therapeutic human dose.
Everyone have a great day. I am optimistic that this Apigenin “treasure hunt” may have a great outcome.
November 21, 2025
Thanksgiving is closing in and it’s been an eventful and busy year. I certainly am thankful for all the researchers who publish research papers, and I thank Google Scholar for creating a search tool to more easily dive into them. I remember when I was completing my MBA at Rutgers in the 1980s, having to drive to the Dana Library on campus and start a search with perhaps card catalogs? OMG ?
Anyhow, I have been wanting to report out about the goodness of Apigenin for a while now, so I have scanned the many research papers I have reviewed, picked two of them, and presented what I thought were the key points in them, as well as links to those points and the entire paper as well. I call it my Apigenin Strategy.
As a result I take two teaspoons of dried Parsley every day in my Year 2 Morning Routine at the Counter, for yet another strategy to fight my PCa with Science. See the video. I am currently using a 2.7 oz bottle of dried Parsley from BJ’s, but Wadkins also looks like a great deal right now. I am ordering this 4.7 oz bottle right now as a backup, since I only have half a bottle left.
Have a great day everyone as well as a great Thanksgiving, probably my favorite holiday.
November 16, 2025
Good Morning Everyone ! I want to focus on Apigenin found in high concentrations in dried parsley. It’s inexpensive, research on it seems robust and research shows Apigenin surely fights PCa. Here is an older 2008 research paper that had some good things to say, and it’s my starting point after about spending 5 hours diving into the literature. I have doubled my intake of dried parsley in my morning routine to two heaping teaspoons.
November 14, 2025
Updated Morning Routine
Over the last year, I have been making some changes to my “Morning Routine at the Counter” that I do after I take my morning pill-based supplements. The first time I recorded my “Counter Routine” was a year ago, and now it’s been two years. So during this morning’s event, I set up the camera again to show the latest of what I do every day.
The changes I remember from the old video involve Rosemary, Parsley Flakes and Grape Seed Oil.
Rosemary
The old Rosemary Flower has been replaced by new Rosemary finely ground which should improve digestibility/absorption. This forms the bedrock of my Ursolic Acid Strategy, as Rosemary probably sources most ursolic acid supplements. I like taking ground Rosemary not only for its ursolic acid, but also for its carnosic acid and rosmarinic acid. And there are several other things in Rosemary that are only lightly researched that are also promising.
Parsley Flakes
Parsley Flakes contain apigenin in wildly higher amounts than any other known substance. As I re-review the positive benefits of apigenin found below in my November 9 post, I’m starting to feel like apigenin deserves more research and looks to be rising in importance. I will probably be creating a separate Apigenin Strategy as well as upping my dose to two heaping teaspoons in my Morning Routine !
Grape Seed Oil
I do not remember at this moment how Grape Seed Oil recently got on my radar, but a quick Google Scholar Search of ” prostate cancer and grape seed oil “, limited to years 2021 and beyond presented over 9,000 research papers. The third one on the list was purple, not blue, (showing I have clicked into this resource recently) and so I took a second look and skimmed it another time. This quick review refreshed my memory on Grape Seed Oil’s goodness. Have a look at the research for yourself, as I am running out of ‘research gas’ for now so a summary here won’t be doable immediately. I am excited to be left with a few new avenues of research to expand my knowledge and improve my self-treatment. Be on the lookout for my summary in the upcoming week !
Other Doctoring
I just got back from my cardiologist yesterday, and he said my numbers are fantastic, and that I present as a ‘young 70 year old’, with zero swelling in my legs, feet and ankles, something I was having a big problem with two years ago before I went vegan and started taking all these supplements. He suggested that I have revversed out some, and then halted the aging process from a cardiac perspective. I get another review with him in six months.
Have a great day everyone !
November 11, 2025 – Veterans’ Day
My Father and Brother were Veterans, and I remember them today as I do most other days, without it being a day of remembrance. While my Veteran Brother passed last year and he knew all about the internet, my Father passed in 1987, and all we had at that time was UseNet if anyone may remember that. It was a slow motion internet where Bell Labs machines and other University Machines would batch process messages at night. Each machine hop would take a day! Messages from Holmdel to MIT could take a couple of days to be delivered.
If my Dad could only see me now; he would say, “WoW”. He supported my interest in Ham Radio as a kid, which started me on my journey through Rutgers Electrical Engineering College and then Computer Engineering. My Dad was a Radio Man in the bivouac tent, at or near the front lines in WWII.
Research Shows Zinc fights Prostate Cancer
As I did a post mortem of the Parsley/Apigenin research from a couple of days ago, I ran across this remnant of my investigations. It’s title is ” Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management. “
After reviewing the paper for a while, my summary and what I expect to do about what I learned here is as follows:
Zinc by itself as a supplement probably does not fight PCa. Despite the fact that prostates with high concentrations of Zinc seem to go hand in hand with low growth rates of PCa, a zinc supplement by itself does not bind with key enzymes that can chop up PCa.
Zinc requires the presence of curcurim, quercetin, resveratrol, and/or epigallocatechin-3-gallate to enhance the bio-uptake of Zinc in the prostate. There are quite a few nuanced arguments about which does what. However, it seemed clear to me that Zinc concentrations in the prostate were significantly increased in this scenario.
What I will now do
I already take curcurim, quercetin, and resveratrol on a daily basis, so I will be selecting a zinc supplement and adding that to my morning routine. I should also be looking at the level of zinc I am already getting from my diet. The epi-3-gal will require more research.
November 9, 2025
Researching “Parsley fights Prostate Cancer” yields some very interesting and useful results.
I liken conducting research using Google Scholar to a treasure hunt, where I dig hole after hole, finding nothing. And then every so often, I find some treasure at the bottom of a hole.
While I was reviewing my Morning Routine videos last night, I noticed they needed some freshening up. In particular, I noticed my latest routine includes a heaping teaspoon of parsley, resulting from a reader suggesting that apigenin was something they had found was an effective PCa fighter. After looking into it a while back, I agreed, and I learned that dried parsley contains a lot of apigenin, an amazing amount compared to anything else currently known. So I bought a container of dried parsley and added that to my morning routine mixture.
This morning I decided to learn more about apigenin and how it fights PCa, but at first I couldn’t remember the name of this phytochemical and chose to Google Scholar “Parsley fights Prostate Cancer” instead. After an hour or so scanning a bunch of research papers I would either quickly or eventually reject (the treasure hunt’s empty holes), I ran across one that focuses on apigenin. The paper takes a microbiologic viewpoint, addressing the microbiological pathways associated with the formation, growth and spread of PCa, and how phytochemicals such as apigenin interrupt these pathways. I like research papers like these, because the questioning is no longer about whether or not something is a PCa fighter or not, but instead explores details on how that occurs.
Here is one of the paper’s schematic diagrams of anti-prostate cancer signaling molecules and pathways for several phytochemicals, including apigenin found in Parsley. This diagram and this paper reaffirms that research supports what I doing to fight my PCa. Note the diagram also addresses the PCa fighting mechanisms of quercetin, resveratrol, and curcumin. These are also supplements I continue to routinely take.
I then turned to another research paper which describes the effects of apigenin on PCa, as well as other plant based biologics which fight PCa. While this is a recent paper as of February 2025, the chemistry described within relists many of the ones I take as supplements or as part of my diet.
A schematic of PCa fighting biochemistry from this paper can be seen here below. Notice that it is largely a laundry list of what I have come to learn on my own, piece by piece, over the last two years: resveratrol, quecertin, ellagic acid, piperine, sulforaphane, etc. And it look like I need to be examining triptolide, which I have just heard about for the first time right now.
In summary, these two papers yet again affirm that I am on the right track in slowing down, stopping, and/or reversing PCa growth using AS methods that are way less harmful to the non PCa cells in my body, allowing me to slow down, or stop PCa progression, and run out the clock on irreversible aggressive PCa treatments.
November 8, 2025
Research shows Pomegranates, Punicalagin, and Punicic Acid Fight PCa
The National Institute of Health (NIH) National Library of Medicine calls out pomegranates and its constituents (what it’s made of) fight cancer in general, as well as specifically fight PCa growth and spread by killing it and restricting the creation of blood-flow pathways. The publication also goes into great detail itemizing pomegranate constituents, defining associated chemistry, and tapping into research papers showing the mechanisms by which PCa is killed and its spread restricted. This publication also delves into possible toxicity of pomegranate consumption and finds no toxicity study that reveals negative outcomes, while citing that pomegranates have been documented as a food and medicine for at least 2,000 years.
Some definitions for clarity
Punicalagin and punicic acid are both important compounds found in pomegranates, but they are different. Punicalagin is a large polyphenol (tannin) found mostly in the peel and juice, while punicic acid is a fatty acid found almost exclusively in the seeds. This means they have different primary sources within the fruit and different chemical properties. Punicalagin is known for its antioxidant properties, and punicic acid is a key component of the seed oil.
Punicalagin
- Type of compound: A large polyphenol, specifically an ellagitannin.
- Location in the fruit: Primarily found in the peel and juice.
- Function: It’s a powerful antioxidant that breaks down into ellagic acid, which then provides antioxidant benefits. It also has various other health benefits, including anti-inflammatory and anticancer properties.
Punicic acid
- Type of compound: A fatty acid.
- Location in the fruit: Almost exclusively found in the seeds, making up a large percentage of the seed oil.
- Function: It is a key component of pomegranate seed oil, which is used in cosmetics and has potential health benefits, including anti-inflammatory and neuroprotective effects.
A second paper on Pomegranates and Punicic Acid , I ran across early in my research back in 2023, still remains important. The depth of research in this area is astounding. I started drinking pomegranate juice to lower my PSA. Later I learned how well it goes with luteolin and elegiac acid.
November 6, 2025
Review and Critique a PCa Trial Informed Consent Form
In the past, I tried to get involved in the PCa experimental trials process. While I have yet to be selected for a trial, I did receive a request to post this opportunity to participate in reviewing an Informed Consent Form. (ICF)
I, myself, submitted an application to join this cohort of PCa subjects tasked with reviewing the ICF document. It’s run by M3 Global, who claims to pay $350 in return for me reading the ICF and answering questions about it. I am in the middle of doing that, and it appears legit, so I am posting about it here so others may consider doing it.
It’s my understanding that I may receive future opportunities to participate in experimental studies, something I am interested in exploring. Anyway, this link should take you to the application form. I have been accepted into the cohort, but I have not completed this effort. When I do, the opportunity for others to get involved will be gone, so I am telling you about it now for your consideration.
November 3, 2025
Well, here I am, 2 full years into my AS journey. I feel better than ever, and my PCa seems under control.
Two years ago, it was the 30 year Oxford Study that gave me a rationale for choosing AS over surgery or radiation. The Oxford Study reported out after 15 years into the study. That showed evidence, based on 1500 PCa patients in three 500 man cohorts, that AS had the same 3% mortality rate as surgery, or radiation. It should be noted that ASers were also taking testosterone suppression drugs that I am not taking, and that I am vegan dieting, as well as taking anti PCa supplements.
And recently, I ran across this 2024 research paper, entitled. ” Has Active Surveillance for Prostate Cancer Become Safer? Lessons Learned from a Global Clinical Registry ”. It comes to the conclusion that the answer to this question is a resounding ‘Yes.” ( 1 )
My summary analysis sounds pretty encouraging, as does the paper. Take a look at both, and consider commenting on the quality of my summary.
Welcome to November. Two years down, twenty to go, or I call I win if I die of anything else other than PCa while still on AS. I also look forward to new developments in the field that I will be able to take advantage of. Thanksgiving is around the corner, and a short Christmas cruise down the Atlantic Coast will be my first Holiday Cruise. I’m not waiting until another year; now is the time.
Best wishes to everyone !
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