Month 13

January 25, 2025 update

Well, for one, it’s my twin daughters birthday. They helped me get this site going and encouraged me along the way.

My second biopsy is February 7. It’s not necessary like the first one since my tumor is low suspect for PC, but since I am already on AS, I will take another look. And we all get some more tissue science with which to evaluate the performance of my activities.

Third, I took a lot of this good stuff, and put it in the form of a kindle book.

There is nothing in the book you cannot find here, it’s just rearranged in kindle form and now you will can have those benefits, if you wish. It also serves as a backup of the data from is website. My webmaster (my daughter) tells me the hosting service regularly backs up the site, but to restore it to another site to test it would be a royal pain. So having this in book form preserves a large part of the information.

January 18, 2025 update

My Urologist Interprets latest MRI

Well, I met with my urologist about my latest MRI. His said my overall condition is improving, which is surprising to him, and in approximately the 1,000 patients he has treated over the last 7 years, I am the only one who has experienced reduced PC tumor volume without any treatment proscribed for them.

I told him about my ursolic acid strategy and my pomegranate seed oil strategy, and this time my urologist listened more closely to what I had to say. In previous meetings, when I described the details of what I am taking, he never commented on that directly other than “Keep doing what you are doing.” But now with MRI evidence of PC tumor volume reduction as well as the 13 months of steadily dropping PSA, he took it a step further and said, “Whatever you are doing, it is responsible for your PSA dropping as well as the reduction in PC tumor volume.” As I discussed it further, he conjectured that whatever I am doing, it appears to result in something similar to taking Finasteride: the reduction in PSA, the reduction in tumor volume, the reduction in prostate volume. These, he said, were consistent with taking Finasteride, but since he had not proscribed Finasteride for me, and “these results just do not happen by themselves, untreated”. So then my urologist said, “What you are doing must be the reason for your favorable results.”

He continued by stating that what was puzzling to him was how it appears that “Whatever I am doing” has eradicated some Grade 4 PC, something that Finasteride in his experience, never does. I asked him how he came to that conclusion, since my calculation yielded a tumor shrinkage of 92% leaving 8%, and that my tumor was 10% Grade 4, 90% Grade 3. It would seem that perhaps what remained of the tumor was, in fact, now just the Grade 4? Then, he said,“Well that might be so, but your original PI-RADS Category 4 Lesion is no longer identified.” What I asked what “no longer identified” meant, he said, “That tumor is gone.” And he continued, “What you have now is another, much smaller tumor, PI-RADS 3, with only a 20% chance of malignancy, so there is no urgent need to perform a biopsy at this time. The tumor that is gone was PI-RADS 4, more dangerous.”

What? Well that blew my mind. After further discussion, my urologist said that my case was a very curious one indeed. The apparent eradication of Grade 4 PC as seen on my second MRI he found remarkable. “While I am very interested in what the biopsy tissue in the area of the previous tumor would reveal, I cannot recommend a biopsy right now.” “A tissue sample of the area would be significantly more definitive than an MRI scan.”

What was going on? I certainly found the whole bloody 3 months biopsy aftermath more than just unpleasant. And my urologist is not recommending it. I have to say I also am interested in what a second biopsy would reveal, but I don’t want to go through that again.

“What am I now? A giant mouse?”, I ask my urologist jokingly. Take one for the Gipper? (I know it’s “Win one”) I have already characterized myself as an “experiment of one”. So why not?

Anyhow, after further wrangling, a fair amount of angst, and probably the longest doctor visit I can remember, I decided to go ahead with scheduling a second biopsy. Ouchies. In the name of Science. lol.

January 15, 2025 update

Tomorrow is the big day for a discussion with my Urologist about my 2nd MRI and how that compares to my first one. Yes my PSA dropped, and the measured diameter of the primary tumor was less, but what will my urologist say about that and the other details in the MRI reports?

Also, I happened by the kitchen, and this was out there. It looks so nice, so I decided to take a picture of what I take for granted: Eating Fresh Foods.

January 2, 2025 update

Happy New Year Everyone. It’s January 2nd 2025, 5am, and my 2nd MRI report is in. I nervously open the MyChart and begin looking at my results.

Can it really be? A reduction in my tumor from 1.4 cm to 0.6 cm? The restricted diffusion at the apex of my prostate is no longer identified? My prostate is smaller? My PSA density dropped from 0.052 to 0.03?

AM I REALLY DOING IT? With just Diet, Supplements, and some Exercise? Oh happy day!

Both doctor appointments are in the near future, but my interpretation of the results looks strong so far. I looked up the urologist appointment, it’s on Jan 16th. I need to delve into the MRI details some more, and make a list of questions for that appointment, but this I know:

  1. The MRI was done at the same facility
  2. The MRI was completed on the same MRI machine.
  3. The same physician interpreted the results, created the comparison, and issued his impression

Is my PC tumor actually 92% smaller than it was 13 months ago?

Of course I can’t wait to speak to my doctors, but that won’t happen until my appointments. So as a math teacher I compare volumes with diameters of 1.4 cm and 0.6 cm. The radius is cubed in the volume formula, so I will use 0.7 and 0.3 as starting and ending radius. (0.7)3 = 0.343 . (0.3)3 = 0.027. The ratio of 0.027/0.343 = 0.079 or 7.9%. My tumor volume is only 8% of what it was 13 months ago? That means the reduction was 92%. WoW.

Oh, Happy New Year to me. I will report out more complete information when I get it.

Thanks everyone for your advice and support. While I understand PC can be a tricky beast, and it could be too early so say what I am doing is curing me a little at a time, certainly it’s a step in the right direction.

These links 1) tell My Story, 2) describe My Strategies, and 3) list My Supplies.

Summary Review

  1. My PC tumor appears to be 92% smaller
  2. PSA reductions for me do seem to indicate reductions in tumor size.
  3. My Strategies are keeping me on AS, without a second biopsy
  4. I am safer than ever.
  5. I just keep following this course of action and I should expect further improvement.

Comments

22 responses to “Month 13”

  1. Do you have an email I can send you to learn more about your approach? Or a phone call I can give you?

    I am a 41 year old that was diagnosed last summer with prostate cancer, Gleason 3+4 and PSA of 4.5.

    I have RALP scheduled for 01/31/25. It’s coming quick. It would be good to talk to you about this.

    Thanks

  2. Wow. This is an amazing result. I’ve had high PSA for years as a result of bph. A biopsy a couple years back showed High Grade PIN,abnormal tissue which used to be considered pre cancerous. I’m learning a lot from your blog. One question and I apologize if it’s been addressed already I have is do you take supps with food or empty stomach?
    Thanks for all the info.

    1. ikr? 80% reduction seems so extreme. I also found it amazing and awesome. That takes a huge amount of pressure off me. I take things mostly with some food.

      1. You have my highest admiration just for being able to drink cranberry juice.

        1. 100% unsweetened cranberry juice is rough to be sure ! That’s why I chase it with my pomegranate juice mixture.

          While Rosemary leaves contain the highest concentration of ursolic acid of any known source, as well as many other things that are good for me (see Table 1), cranberries contain two rare derivatives of ursolic acid: cis-3-O-p-hydroxycinnamoyl ursolic acid and trans-3-O-p-hydroxycinnamoyl ursolic acid.

  3. I’m struggling with that 81% reduction calculation.

    Assuming the growth was spherical on each occasion it had been measured, when it had a 1.4cm diameter it would have had a 1.4361cc volume. And when the diameter was 0.6cm the volume would have been 0.1131cc.

    That would make the reduction 1.323cc, i.e. a 90.5% reduction of the original size.

    Of course, there are some assumptions there around the growth being spherical.

    1. I think your calculations are better. I am cubing a percentage which is inaccurate. Using your volume calculations of 1.4361 and 0.113 which I duplicated, I use 1.323/1.436 to get 92.1%. And then properly using the proportions rule for similarly shaped objects it’s a comparison of the cubes of the radius or 0.7^3 vs.0.3^3. Here I also get 92.1. Time to check and double check. It will be interesting to see if the urologist report mentions a reduction percentage. My report did not call out a specific tumor volume. Thanks for taking a look at it !

      1. I realised I’d not mentioned the assumption that the cell density (numbers per cc) would be the same in the original tumour and the reduced version of it.

        I know what I did to get 90.1%. I transposed the 3 and the 6 in 1.436, i.e. I used 1.463 instead of 1.436. (As I get older I find it harder to retain numbers in my head – a real pain when given a phone number.)

        1. working in groups is always more fun than working alone. 🙂

  4. Impressive results! It is also surprising considering that there are many other supplements you could have added (e.g. EGCG, quercetin and berberine).

    Also very interesting that your PSA dropped consistently over a couple of months. I’ve seen my PSA drop from 3.57 to 2.45 (i.e. 31%) in 71 days (between August and October 2024), but it then spiked and came back down over the past 2 months and is now stable at around 2.8. (Since I wanted more data, I went for a PSA test much more often than every 3 months.) It corresponded to a 26% reduction in tumour volume, but I also started out with a larger tumour: 3.18 cm^3 (which is now at 2.36).

    1. I am taking quercetin as part of my resveratrol strategy. Congrats on the tumor volume reduction. Were those MRI tumor measurements you used to calculate 26% ? Thanks for your story.

      1. Yes, they were MRI measurements. The tumour volume was included in the MRI reports (as well as 3 measurements which I suppose are in orthogonal directions, but which aren’t helpful to determine volume).

  5. Thank you for documenting your battle. It’s impressive and I’m trying to distill all the info you’ve written into an action plan for me.

    I was diagnosed with 3+3 in 2017. I immediately switched to a vegan diet and started walking briskly daily. I had also been taking 1mg finasteride for close to 20 years. Since then, my cancer has grown a bit and also been upgraded to 3+4.

    Most recently, after biopsy #3, the Gleason 4 component seems to have grown and cells have been identified just outside the prostate (EPE – Extra Prostatic Extension).

    I’ve been taking certain supplements for several years (sulforaphane, B12, D3/K2, turmeric) and recently added POMI-T and white button mushroom extract. I also switched from Finasteride to Dutasteride as studies have shown it can decrease tumor size by 31% within 3-6 months.

    I’m a little frustrated that all of my efforts haven’t been rewarded quite like yours have, but I’m glad I stumbled onto your site. I’m wondering what I should pursue from your list before treatment is mandatory.

    I just switched to City of Hope (from Kaiser) for 2025 and will most likely have another round of tests before treatment is strongly suggested. I’d love to surprise my new doctors with a diminished tumor. Is it possible that could occur within 3-5 months from now?

    One other note: my prostate is tiny (<20cc) due to 25+ years of finasteride. As a result, my PSA has never been over 0.7. So, I wouldn't expect my PSA would go down too much even if the tumor decreased by 50%.

    Any thoughts are appreciated.

    1. While I also take a sulforaphane supplement, I try to get as much sulforaphane as I can by eating broccoli. I mostly eat it raw, although if you mash it up first and wait 45 minutes before cooking you preserve the goodness of broccoli as I have come to understand it. Here are links to my site for sulforaphane.

      My two main strategies are my ursolic acid strategy, and pomegranate seed oil strategy. Both of these strategies require several other things to be taken with them. I believe these two strategies work for me best, at least for now, based on what I read in University Research Papers. While my reduction of tumor size I have interpreted as a 92% reduction based on comparative linear diameter measurements, I am still waiting to discuss the latest results with my doctors.

      Of course, I am doing all 10 of my strategies at once, so it’s impossible to tell which are doing what for me, and it’s extremely risky behavior taking all these different things at once that haven’t been tested for toxicity or drug interactions. And I am not a doctor and make no recommendations of any course of action for anyone else. I am only an experiment of one person, but I do all I do while running this by my doctors, who haven’t summarily discharged me as a patient. lol. Thanks for your post.

    2. As a secondary comment, the Punicic Acid in pomegranate seed oil I believe may be responsible for wiping out the 10% grade 4 potentially metastatic PC. If I were in your situation I would start slowly but then increase PSO to whatever I could tolerate. Of course I cannot in good conscience advise you to do anything since such an act would be so risky. But for me I want to keep my prostate at all costs. I am not a doctor. Do not try this at home. you know. I am only willing to assume the risk for myself.

      1. How much PSO are you taking?

        So far, I’m taking 1 softgel (600mg) a day per the directions. I’m also drinking two or three big gulps (not 7-11) of pure cranberry juice followed by the same of pomegranate juice first thing in the morning.

        I’m taking all the other supplements you mention except Resveratrol. I read some conflicting reports. Also, ChatGPT seems to think that the most promising supplements are PSO and carnosic acid (rosemary, etc).

        I have my first appointment at City of Hope on Thursday. I suspect they’ll order a PSMA PET scan and follow up MRI to see what the status is.

        I’m really hoping that all the things I’m doing, plus the new things I learned from your blog will show signs of saving me from a surgery by the time I actually have the scan/MRI.

        Thanks!

        1. It sounds like you have a lot of good things going for you. I take a heaping teaspoon of ground pepper to improve the bioavailability of the ursolic acid and other things. I like to be sure I am getting the elegiac acid and luteolin with my PSO. Research shows it kills PC at at little as 5uM/l and is super effective at 30 uM/l.

  6. In reading about your initial diagnosis, you and I are similar in many ways:

    Same diagnosis: Gleason 3+4 / similar tumor size
    Treatment recommended: surgery sooner than later

    Differences:
    My PSA was/is very low at 0.7 vs yours was high at +6.x
    You were taking testosterone supplements and I was on Finasteride 1mg (later Dutasteride .5mg)

    Questions:
    How were you able to differentiate the effect of stopping testosterone vs starting the supplements? Is there any way to know if stopping the testosterone was the main driver of reversing your PCa vs the supplements?

    Do you have any advice for me on how to find an expert who can help me determine if Finasteride/Dutasteride is helping or hurting my cancer fight?

    I believe strongly in what you’re doing, but somehow I have to personalize for my own battle and time is running out.

    Thanks!!

    1. According to my Urologist, stopping testosterone could account for no more than my first PSA drop, since it leaves my system within a month, and my PSA tests are 3 to 4 months apart. So after 3 drops over 11 months, my Urologist says “what you are doing is the driver of your PSA reductions, and apparent reduction in tumor size.”

      According to my Urologist, Finasteride will shrink grade 3 cancer, but has no effect on grade 4 cancer.

      Good luck and good science on what you choose to do. My second biopsy will guide my next step. Feb 7.

  7. Louie Avatar
    Louie

    In 2021 I was diagnosed with prostate cancer gleason 3/3 and was put on active surveilance with biopsy every 18mos. I started taking a combo of turmeric, ursolic acid and resveratrol daily. PSA went down from 16 to 2.8. I had my 3rd biopsy 3 weeks ago result: all samples came out benign.

    1. Awesome results Louie. Best of luck going forward.

Leave a Reply

Your email address will not be published. Required fields are marked *