mRNA therapy represents a revolution in PCa treatment

I have known for a while that the same mRNA techniques used to create COVID 2 vaccines have moved on to create cancer therapies. Some are very successful, very expensive, but restricted to cancers outside the realm of PCa. And I have been wondering for a while what was happening in the world of mRNA with respect to PCa. Then I ran across this research paper exactly about that. It was published in the journal called Nature, arguably the most prestigious scientific journal in the world.

I am capable of reading this paper, even if it is slowly, but surely, because I have been reading and interpreting research papers for some time. And while I do know this will take me some time, I wish to create a summary of what the paper says for my own understanding as well as the understanding of others.

I believe Step 1 in understanding of exactly how revolutionary mRNA vaccines can become in the fight against PCa, it’s useful to see how CRISPR technology works. CRISPR helps some types of mRNA vaccine approaches and CRISPR is essential for others. Two reasonably short videos can give you perspective on how completely different CRISPR gets the results it does as well as why what it does has been completely unobtainable without it.

First is a general CRISPR video from the Kurzgesagt series. Kurzgesagt in German means “in a nutshell.”

Here is a youtube link to the Kurzgesagt CRISPR video. Curing cancers gets a cursory examination around 6:30 if you want to just see that, but I encourage you to watch the entire video.

The second video is from Acapella Science that mentions a lot of things, from CRISPR mechanisms (how it works) to some of its major accomplishments and how rapidly they have been occurring. It’s set to the tune of “Mr. Sandman”, which for me, makes it also entertaining. Here is the Acapella Science CRISPR video. And here is a link to the lyrics, in case you wish to dig into more of what is being said here without having to constantly stop and start the video.


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