{"id":649,"date":"2025-04-13T08:29:10","date_gmt":"2025-04-13T08:29:10","guid":{"rendered":"https:\/\/iloweredmypsa.com\/?p=649"},"modified":"2025-04-29T14:09:10","modified_gmt":"2025-04-29T14:09:10","slug":"months-15-and-16","status":"publish","type":"post","link":"https:\/\/iloweredmypsa.com\/?p=649","title":{"rendered":"Months 15 and 16"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">April 29, 2025<\/h4>\n\n\n\n<p>Who would think after a long break not posting anything, then the day after the April 28th post, I get a reply to a <a href=\"https:\/\/www.reddit.com\/r\/ProstateCancer\/comments\/1h3t232\/comment\/mpmoome\/?context=3\">5 month old social media post<\/a> where the poster talks about his Dad who was diagnosed at 63 with PCa who did something similar to what I am doing, and he just celebrated his 94th birthday ! No operations, no chemotherapy, no radiation. He dropped his PSA from 7 to 2 and kept it there with diet and supplements.<\/p>\n\n\n\n<p>Here is an image of the post.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"461\" height=\"1024\" src=\"https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/04\/WhatsApp-Image-2025-04-29-at-06.20.20_c4e4f9a0-461x1024.jpg\" alt=\"\" class=\"wp-image-656\" style=\"width:308px;height:auto\" srcset=\"https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/04\/WhatsApp-Image-2025-04-29-at-06.20.20_c4e4f9a0-461x1024.jpg 461w, https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/04\/WhatsApp-Image-2025-04-29-at-06.20.20_c4e4f9a0-135x300.jpg 135w, https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/04\/WhatsApp-Image-2025-04-29-at-06.20.20_c4e4f9a0-768x1708.jpg 768w, https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/04\/WhatsApp-Image-2025-04-29-at-06.20.20_c4e4f9a0-691x1536.jpg 691w, https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/04\/WhatsApp-Image-2025-04-29-at-06.20.20_c4e4f9a0.jpg 921w\" sizes=\"auto, (max-width: 461px) 100vw, 461px\" \/><\/figure>\n\n\n\n<p>I looked into the Ron Gellatley book. It&#8217;s $39 published in 2001. Yes it&#8217;s a great thing to know it happened in the past, but I am not ready to pay $39 for it, when I have been creating a similar, more modern version of that book that has been taking advantage of a huge amount of scientific research not available at that time. Nevertheless, there could be some good information there, I&#8217;m just ready to plunk down that much for it,<\/p>\n\n\n\n<p>Here is <a href=\"https:\/\/iloweredmypsa.com\/?p=482\">my book for a mere 4.99<\/a>, and I try to run the Amazon freebee they allow every so often.<\/p>\n\n\n\n<figure class=\"wp-block-image is-resized\"><a href=\"https:\/\/www.amazon.com\/Lowered-My-PSA-Forward-Thinking-Research-ebook\/dp\/B0DV1RWJHY?crid=14N5NABHTLONF&amp;dib=eyJ2IjoiMSJ9.xeOgq9q3GO9IVxQOWE8AHayF9EiUEKmOxXhWBbrfyno.c0iMEPGjxFXuZS_N01aXHcH42wIwJEw1FvTdOIbyBiI&amp;dib_tag=se&amp;keywords=i+lowered+my+psa&amp;qid=1737816269&amp;sprefix=i+lowered+my+psa%2Caps%2C88&amp;sr=8-1\"><img loading=\"lazy\" decoding=\"async\" width=\"644\" height=\"1024\" src=\"https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/01\/book-1-cover-644x1024.jpg\" alt=\"\" class=\"wp-image-602\" style=\"width:125px;height:auto\" srcset=\"https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/01\/book-1-cover-644x1024.jpg 644w, https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/01\/book-1-cover-189x300.jpg 189w, https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/01\/book-1-cover-768x1222.jpg 768w, https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/01\/book-1-cover.jpg 943w\" sizes=\"auto, (max-width: 644px) 100vw, 644px\" \/><\/a><\/figure>\n\n\n\n<p>For me, it&#8217;s not about the proceeds, it&#8217;s about getting feedback like above that confirms what I am doing. And I also get occasional good, new ideas from others. Whatever I can do to live to 94 without symptoms and at the same time, take good notes and make them available to others who are looking for such solutions sounds like a plan.<\/p>\n\n\n\n<p>Welp, off to the gym at 8am.  Don&#8217;t really feel like it, but I know it&#8217;s good for me.  I will need new legs in a couple of months to be able to walk the hills of Baguio.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">April 28, 2025<\/h4>\n\n\n\n<p>Continuing my focus on punicic acid.  I feel great.  I have been going to the gym more.  I mostly do a stationary bike for about an hour.  I started at level 21, and have upped it to 23 and then some 25 recently.<\/p>\n\n\n\n<p>I did get contacted by a Phase II drug trial patient search company and I am on the list for potential acceptance screening. It&#8217;s a WEE-1 inhibitor.  Sounds a little dangerous.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Well, off to the gym for now.  I will report out more when I have it.  Anyone&#8217;s opinion on WEE1 phase II trials is welcome.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">April 13, 2025<\/h4>\n\n\n\n<p>It has taken a while for me to assess my latest results and then decide how to proceed.<\/p>\n\n\n\n<p>Grade 4 is still present, but it&#8217;s impossible to say whether or not I have more of it, even with one at 20%. My urologist says I am pretty much in the same place I was a year ago, although the one core with 20% is higher than the 10% I had last year.  He did not comment on the fact that the first lesion had disappeared. To me, the organized lesion has apparently broken up, and that  could be a good sign.  I can&#8217;t get an opinion on that.  Since a fair amount of activity takes place on the surface of the lesion, and punicic acid attacks the blood flow structures of PCa, I am hopeful this is a good sign.<\/p>\n\n\n\n<p>I am continuing AS. My hair has darkened some, I have fewer face wrinkles, and the sensitivity and functioning in romantic situations have improved substantially even though I no longer take testosterone supplements or use trimix.  This is the major reason to remain on AS, along with none of the other side effects of surgery. <\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Punicic Acid Focus<\/h3>\n\n\n\n<p>I have shifted my plan somewhat. I am now taking double the punicic acid in the form of pomegranate seed oil, putting me at 10,000 mg \/ day. I have also doubled my elegiac acid and luteolin supplements. Here is the <a href=\"https:\/\/scholar.google.com\/scholar?as_ylo=2024&amp;q=punicic+acid+and+prostate+cancer&amp;hl=en&amp;as_sdt=0,31\">list of research<\/a> that has me focusing on this at the moment. My <a href=\"https:\/\/iloweredmypsa.com\/?p=385\">pomegranate seed oil strategy is here<\/a>. Pomegranate seed oil is mostly punicic acid, also known as Omega 5.<\/p>\n\n\n\n<p>I wish I could find a way to get a punicic acid blood test.  I also want to get into any human trials that use punicic acid therapy.  Both seem a way out there.  I need to start going to science conferences where the authors of the key papers present their findings.  I need to meet and speak to these scientists.<\/p>\n\n\n\n<p>This last idea is probably pretty important.  I have been to other science conferences when I was doing enzyme research.  I need to figure this one out.<\/p>\n\n\n\n<p>I am still being guided by an <a href=\"https:\/\/www.cell.com\/iscience\/fulltext\/S2589-0042(24)00996-9\">important research article on punicic acid on my site<\/a>.<\/p>\n\n\n\n<p>I will use this occasion to review my PSO Strategy (the focus of which is punicic acid)  again to clarify and improve my thinking. And so is the nature of University-level research science paper reading.  <em>Each re-reading benefits from the knowledge learned between readings<\/em>. <\/p>\n\n\n\n<p>Here is the graph and the analysis that I still focus on.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"468\" height=\"304\" src=\"https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/02\/Punicic-acid-graph-results-2024-by-Perrine-Vermonden-graph-A-only.png\" alt=\"\" class=\"wp-image-611\" srcset=\"https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/02\/Punicic-acid-graph-results-2024-by-Perrine-Vermonden-graph-A-only.png 468w, https:\/\/iloweredmypsa.com\/wp-content\/uploads\/2025\/02\/Punicic-acid-graph-results-2024-by-Perrine-Vermonden-graph-A-only-300x195.png 300w\" sizes=\"auto, (max-width: 468px) 100vw, 468px\" \/><\/figure>\n\n\n\n<p><strong>This graph shows how punicic acid (PunA) kills metastatic prostate cancer<\/strong>. All 6 PC viability curves meet at two points, where they are all alive, point (0,1) top left, and where they are all dead, point(100,0) bottom right. <\/p>\n\n\n\n<p>PC3 dies most quickly, where half are dead (<a href=\"https:\/\/www.google.com\/search?q=ic50&amp;rlz=1C1ONGR_enUS961US961&amp;oq=ic50&amp;gs_lcrp=EgZjaHJvbWUyBggAEEUYOdIBCDQzNDdqMGo3qAIIsAIB&amp;sourceid=chrome&amp;ie=UTF-8\"><strong>IC50<\/strong><\/a> <strong>means half are dead<\/strong>) at a very low concentration of 1.1 <em>\u00b5<\/em>M ( 1.1 millionth of a Mole per liter). The table to the right lists the PunA concentrations for IC50 for all six cancer cell lines. On the graph, that is the point where &#8220;Relative cell viability&#8221; = 0.5. Each curve passes through the height of 0.5 at different PunA concentrations. Those points of concentration for each curve are listed in the table. <em>Note the x-axis is logarithmic.<\/em> Find the definitions of the six cell lines and some details at the bottom of <a href=\"https:\/\/iloweredmypsa.com\/?p=509\">this post<\/a>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Ursolic Acid still counts for me<\/h3>\n\n\n\n<p>I also am planning for a massive increase in ground rosemary intake.  Rosemary has lots of ursolic, carsonic, and rosmaranic  acid. See the <a href=\"https:\/\/iloweredmypsa.com\/?p=320\">Ursolic Acid Strategy here<\/a>. I have found a good supplier of ground rosemary, and I need to get a lot of it, which will take a special effort to make it economical. I will also need a big supply of ground black pepper for absorption.  I will report out on that when I get that going.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>April 29, 2025 Who would think after a long break not posting anything, then the day after the April 28th post, I get a reply to a 5 month old social media post where the poster talks about his Dad who was diagnosed at 63 with PCa who did something similar to what I am [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-649","post","type-post","status-publish","format-standard","hentry","category-my-psa-story"],"_links":{"self":[{"href":"https:\/\/iloweredmypsa.com\/index.php?rest_route=\/wp\/v2\/posts\/649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/iloweredmypsa.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/iloweredmypsa.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/iloweredmypsa.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/iloweredmypsa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=649"}],"version-history":[{"count":10,"href":"https:\/\/iloweredmypsa.com\/index.php?rest_route=\/wp\/v2\/posts\/649\/revisions"}],"predecessor-version":[{"id":666,"href":"https:\/\/iloweredmypsa.com\/index.php?rest_route=\/wp\/v2\/posts\/649\/revisions\/666"}],"wp:attachment":[{"href":"https:\/\/iloweredmypsa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/iloweredmypsa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/iloweredmypsa.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}